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Theurine pH rises because the body cannot excrete acid. Patient gives her pain a 4 on a pain scale of 1–7 where 1 is no pain and 7 is excruciating pain.3
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Once a population PK model for plasma and bone has beendeveloped, it can be employed in Monte Carlo simulations to predict the expectedconcentration time profiles for other than the studied dosage regimens.
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